上海精准医学研究院系列学术报告（2024年度第2期）1月12日【上海精准医学研究院】

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上海精准医学研究院系列学术报告（2024年度第2期）1月12日

发布日期：2024-01-15 点击次数：

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报告题目：

Histone H3K36me3 Regulates Alternative Polyadenylation

报告嘉宾：

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方东

浙江大学生命科学研究院研究员/博士生导师

2007-2012 Tsinghua University, Ph.D.

2003-2007 Tsinghua University, B.S.

Research Experience

2018-Present, Principle Investigator, Life Sciences Institute, Zhejiang University

2016-2018, Associate Research Scientist, Institute for Cancer Genetics, Columbia University Medical Center

2015-2016, Senior Research Fellow, Department of Biochemistry and Molecular Biology, Mayo Clinic

2012-2015, Research Fellow, Department of Biochemistry and Molecular Biology, Mayo Clinic

时间：2024年1月12日 16:00-17:30PM

地点：浦东新区锦尊路115号2号楼1楼1号报告厅

Histone H3K36me3 Regulates Alternative Polyadenylation

Complex organisms generate differential gene expression through the same set of DNA sequences in distinct cells. The communication between chromatin and RNA regulates cellular behavior in tissues. However, little is known about how chromatin, especially histone modifications, regulates RNA polyadenylation. In this study, we found that H3K36me3 mediated the alternative polyadenylation. Abolish of H3K36me3 resulted in an increase in polyadenylation sites far from gene stop codons genome-wide. These findings reveal that FUS recognizes H3K36me3 that links chromatin-mediated alternative polyadenylation.