报告题目： Molecular and Genetic Mechanisms Underlying Auditory Hair Cell Development and Regeneration 报告嘉宾： 刘志勇 中国科学院脑科学与智能技术卓越创新中心 研究员 1999年-2003年，四川大学华西基础医学与法医学院，获法医学学士学位 2003年-2006年，四川大学华西基础医学与法医学院，获法医学硕士学位 2006年-2011年，美国田纳西大学健康科学中心，获生物医学博士学位 2012年-2016年，美国霍华德.休斯医学研究所-Janelia园区，从事博士后研究 2016年8月-今，任中国科学院脑科学与智能技术卓越创新中心研究员/听觉系统发育再生研究组组长 个人简介： 主要从事外周听觉系统发育和再生的分子机制研究，已在国际学术期刊Science, Cell, National Science Review, PNAS等发表30多篇学术论文。 2017年获国家千人计划青年项目和中科院百人计划资助。现兼任中国生理学会-转化神经分会秘书长，中国细胞生物学会-神经细胞生物学分会，中国神经科学会-神经发育和再生分会委员，中国生物物理学会-听觉语言分会委员及Neuroscience Letter杂志associate editor和Neuroscience Bulletin杂志编委。
地点：浦东新区锦尊路115号2号楼1楼2号报告厅 Molecular and Genetic Mechanisms Underlying Auditory Hair Cell Development and Regeneration
The cochlear hair cells (HCs) are our sound receptors and contain two subtypes: inner HCs (IHCs) and outer HCs (OHCs). Degeneration of HCs is one of the top reasons underlying human congenital and age-related hearing loss. Currently, no effective clinical approach is available to regenerate HCs. Nonetheless, the impressing ability of non-mammals to regenerate HCs prompts us to investigate how the mammalian HCs, IHCs and OHCs are generated as well as whether we can regenerate functional HCs in mammals by taking advantage of those key HC/IHC/OHC developmental genes. In my presentation, I will first discuss how the HC master gene Atoh1 is dynamically and specifically regulated in HCs, followed by discussing how OHC /IHC fates are specified and maintained by Insm1/Ikzf2, and Tbx2, respectively. Finally, I will focus on how to produce the pre-clinical mouse models to mimic the human IHC/OHC death, by which we can regenerate IHCs by dual expression Atoh1 and Tbx2, as well as regenerate OHCs by dual dual expression Atoh1 and Ikzf2 in the non-sensory supporting cells of the damaged cochleae. |
