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研究兴趣
精子发生包括有丝分裂、减数分裂和精子成熟过程。在减数分裂前期I，端粒参与调控同源染色体配对和联会等过程，我们利用结构生物学方法，辅助以突变体小鼠模型系统地研究端粒相关蛋白质复合物调控同源染色体配对和联会的结构基础和分子机制。精子成熟过程产生特定形态与结构的成熟精子以保障精子和卵子的有效识别和融合。临床上很多男性不育病例表现为精子结构的畸形。针对部分遗传因素导致的病例，我们将构建类似于临床病例的突变小鼠模型，研究相关基因突变的致病机理，为畸形精子症患者的临床诊疗提供理论指导。
个人教育经历与工作经历
工作经历：(1) 2017.9-至今，上海交通大学，医学院附属第九人民医院，副研究员(2) 2014.5-2017.8，中国科学院上海生命科学研究院，生化与细胞所，副研究员(3) 2009.7-2013.12，Washington State University，USA，SMB，助理研究员(4) 2005.2-2008.8，Uppsala University，Sweden，ICM，助理研究员 教育经历：(1) 1998.9–2004.7，北京大学生命科学学院，植物学系，博士学位(2) 1994.9–1998.7，北京大学生命科学学院，植物发育及分子生物学，学士学位
代表性研究成果
Yu K#, Huang C#, Wan F#, Jiang C, Chen J, Li X, Wang F, * Wu J*, Lei M* and Wu Y*, Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants. Nat Commun. 2023, 14(1): 767. Ma Y#, He J#, Li S, Yao D, Huang C, Wu J* and Lei M*, Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun. 2023, 14(1): 1506. Lu J#, Zhang C#, Shi S, Li S, Liu J, Wu J, Huang C* and Lei M*, Stoichiometry and architecture of the platelet membrane complex glycoprotein Ib-IX-V. Biol Chem. 2023. Ma Y#, Huang C, Tang T, Wu B, Xue H, Cao Y, Wu J*, Wan B* and Lei M*, Structural and functional insights into CST tethering in Tetrahymena thermophila telomerase. Structure. 2022, 30(12): 1565-1572.e4. Fan Y#, Huang C#, Chen J, Chen Y, Wang Y, Yan Z, Yu W, Wu H, Yang Y, Nie L, Huang S, Wang F, Wang H, Hua Y, Lyu Q*, Kuang Y *and Lei M*, Mutations in CCIN cause teratozoospermia and male infertility. Science Bulletin. 2022, 67(20): 2112-2123. Zuo W#, Chen G#, Gao Z, # Li S, Chen Y, Huang C, Chen J, Chen Z, Lei M* and Bian Q*, Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment. Nat Commun. 2021, 12(1): 5827. Chen Y#, Wang Y#, Chen J, Zuo W, Fan Y, Huang S, Liu Y, Chen G, Li Q, Li J, Wu J, Bian Q, Huang C* and Lei M*, The SUN1-SPDYA interaction plays an essential role in meiosis prophase I. Nat Commun. 2021, 12(1): 3176. Wang Y#, Chen Y#, Chen J, Wang L, Nie L, Long J, Chang H, Wu J, Huang C* and Lei M*, The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope. Nat Commun. 2019, 10(1): 564. Wu J#, Niu S#, Tan M#, Huang C, Li M, Song Y, Wang Q, Chen J, Shi S, Lan P* and Lei M*, Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Cell. 2018, 175(5): 1393-1404 e11. Long J#, Huang C#, Chen Y, Zhang Y, Shi S, Wu L, Liu Y, Liu C, Wu J* and Lei M*, Telomeric TERB1-TRF1 interaction is crucial for male meiosis. Nat Struct Mol Biol. 2017, 24(12): 1073-1080. Huang C#, Jia P, Chastain M, Shiva O and Chai W*, The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells. Experimental Cell Research. 2017, 355(2): 95-104. Hu C#, Rai R#, Huang C, Broton C, Long J, Xu Y, Xue J, Lei M*, Chang S* and Chen Y*, Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex. Cell Res. 2017, 27(12): 1485-1502.
