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研究兴趣
染色质作为生物体遗传信息的载体，其结构与功能受到各种表观遗传调控因子在时间与空间水平上的高度调控，以指导生物体进行遗传、发育、分化、重塑等一系列重要的生命活动。染色质表观遗传调控异常是肿瘤发生发展的重要诱因。黄晶研究员长期从事染色质结构与功能相关的结构生物学研究，重点关注与肿瘤发展密切相关的、调控染色质结构与功能的重要蛋白质复合物和RNA-蛋白质复合物，通过对这些复合物的高分辨率结构解析和细胞水平的功能机制研究，揭示其参与染色质结构与功能调控的分子机理和结构基础，阐明其参与肿瘤发生发展的分子致病机理，并进行以三维结构为指导的靶向药物研发。
个人教育经历与工作经历
2004年毕业于山东大学生命科学学院，获生物技术理学学士学位。2009年毕业于清华大学生命科学学院，获生物学理学博士学位。2009年至2014年在美国密歇根大学医学院，美国霍华德-休斯医学研究所从事博士后研究。2014年至2017年在中科院上海生科院生化细胞所任研究员、研究组长、博士生导师。2017年起在上海交通大学医学院附属第九人民医院上海精准医学研究院任研究员、研究组长、博士生导师。
代表性研究成果
1. Xue, H., Yao, T., Cao, M., Zhu, G., Li, Y., Yuan, G., Chen, Y., Lei, M. & Huang, J. Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature 573, 445-449 (2019) 2. Yao, T., Jing, W., Hu, Z., Tan, M., Cao, M., Wang, Q., Li, Y., Yuan, G., Lei, M. & Huang, J. Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome. Cell Res. 29, 330-333 (2019) 3. Wang, K., Yin, C., Du, X., Chen, S., Wang, J., Zhang, L., Wang, L., Yu, Y., Chi, B., Shi, M., Wang, C., Reed, R., Zhou, Y., Huang, J. & Cheng, H. A U2-snRNP–independent role of SF3b in promoting mRNA export. Proc. Natl. Acad. Sci. 116, 7837–7846 (2019) 4. Wang, X., Kang, J.-Y., Wei, L., Yang, X., Sun, H., Yang, S., Lu, L., Yan, M., Bai, M., Chen, Y., Long, J., Li, N., Li, D., Huang, J., Lei, M., Shao, Z., Yuan, W., Zuo, E., Lu, K., et al. PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis. Development (2019). doi:10.1242/dev.175547 5. Xie, X., Hu, H., Tong, X., Li, L., Liu, X., Chen, M., Yuan, H., Xie, X., Li, Q., Zhang, Y., Ouyang, H., Wei, M., Huang, J., Liu, P., Gan, W., Liu, Y., Xie, A., Kuai, X., Chirn, G. W., et al. The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168. Nat. Cell Biol. 20, 320-331 (2018). 6. Li M, Gou H, Tripathi B, Huang J, Jiang S, Dubois W, Waybright T, Lei M, Shi J, Zhou M, Huang J. An Apela RNA-containing negative feedback loop regulates p53-mediated apoptosis in embryonic stem cells. Cell Stem Cell 16, 669-83 (2015) 7. Huang J, Brown A, Wu J, Xue J, Bley C, Rand D, Wu L, Zhang R, Chen J, Lei M. Structural basis for protein-RNA recognition in telomerase. Nat Struct Mol Biol 21, 507-12 (2014). 8. Zhou H, Liu L, Huang J, Bernard D, Karatas H, Navarro A, Lei M, Wang S. Structure-based design of high-affinity macrocyclic peptidomimetics to block the Menin-Mixed Lineage Leukemia 1 (MLL1) protein-protein interaction. J Med Chem 56, 1113-23 (2013) 9. Huang J, Wan B, Wu L, Yang Y, Dou Y, Lei M. Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. Cell Res. 6, 1078-81 (2012) 10. Huang J, Gurung B, Wan B, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X, Lei M. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 482, 542-6 (2012) 11. Thiel AT, Huang J, Lei M, Hua X. Menin as a hub controlling mixed lineage leukemia. Bioessays 34, 771-80 (2012) 12. Zeng Z, Min B, Huang J, Hong K, Yang Y, Collins K, Lei M. Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA. Proc Natl Acad Sci U S A 108, 20357-61 (2011)
