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研究兴趣
真核生物的基因组在细胞核内折叠为一系列复杂但有序的三维结构，三维基因组结构对基因组的转录、复制及修复等功能起着重要的调控作用。本课题组主要通过遗传学、显微成像以及包括高通量染色体构象捕获（Hi-C）在内的多种基因组学方法，开展以下几个方向的研究：1.解析三维基因组结构形成与调控的分子机制2.探索衰老、生殖与发育等过程中的基因调控机制3.开发研究三维基因组结构与动态的新方法
个人教育经历与工作经历
1998.9–2003.6, 中国科学技术大学, 少年班/生命科学学院, 学士2004.9–2011.5, 伊利诺伊大学香槟分校, 生物物理与计算生物学系, 博士,导师: Andrew S. Belmont2011.7-2017.10, 加利福尼亚大学伯克利分校, 分子与细胞生物学系, 博士后，导师：Barbara J. Meyer2017.10-至今, 上海交通大学医学院, 第九人民医院, 研究员
代表性研究成果
Wang B*, Ji L*, Bian Q#, “SATB1 regulates 3D genome architecture in T cells by constraining chromatin interactions surrounding CTCF-binding sites”, Cell Rep. 2023, 42(4):112323 (# Corresponding author)Chen Q, Dai J#, Bian Q#, “Integration of 3D genome topology and local chromatin features uncovers enhancers underlying craniofacial-specific cartilage defects”, Sci Adv. 2022, 8(47):eabo3648 (# Corresponding author)Zuo W*, Chen G*, Gao Z*, Li S, Chen Y, Huang C, Chen J, Chen Z, Lei M#, Bian Q#, “Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment”, Nat Commun. 2021 Oct 8, 12(1):5827. (# Corresponding author)Bian Q*, Anderson EC*, Yang Q, Meyer BJ，“Histone H3K9 methylation promotes formation of genome compartments in C. elegans via chromosome compaction and perinuclear anchoring” PNAS 2020, 117(21):11459-11470 (* Equal contribution.)Brejc K*, Bian Q*, Uzawa S, Wheeler BS, Anderson EC, King DS, Kranzusch P, Preston CG, Meyer BJ, “Dynamic control of X-chromosome conformation and repression by a histone H4K20 demethylase” Cell 2017, 171:85–102.e23 (* Equal contribution.)Crane E*, Bian Q*, McCord RP*, Lajoie BR*, Wheeler BS, Ralston EJ, Uzawa S, Dekker J, Meyer BJ, “Condensin-driven remodelling of X chromosome topology during dosage compensation” Nature 2015, 523:240-44 (* Equal contribution.)Bian Q, Khanna N, Alvikas J, Belmont AS, “β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications” J Cell Biol. 2013, 203(5):767-83 Bian Q and Belmont AS, “Revisiting higher-order and large-scale chromatin organization” Curr Opin Cell Biol. 2012, 24(3):359-66.Bian Q and Belmont AS, “BAC TG EXPRESS: One step method for high-level, copy number dependent, position independent transgene expression” Nucleic Acids Res. 2010, 38 (11): e127.
